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Efficient Synthesis of Polysubstituted Acylguanidines and Guanylureas

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journal contribution
posted on 23.01.2004, 00:00 by Alan R. Katritzky, Boris V. Rogovoy, Xiaohong Cai, Nataliya Kirichenko, Katherine V. Kovalenko
(Benzotriazol-1-yl)carboximidamides were applied for the preparation of polysubstituted acylguanidines and guanylureas. The reaction sequence utilized mild conditions and gave high yields for final compounds and intermediates. The protocol developed allows for variation of the substituents at all positions of the products.