ol500732c_si_001.pdf (5.94 MB)
Efficient Synthesis of 1,5-Disubstituted Carbohydrazones Using K2CO3 As a Carbonyl Donor
journal contributionposted on 2014-05-02, 00:00 authored by Jun Wen, Chu-Ting Yang, Tao Jiang, Sheng Hu, Tong-Zai Yang, Xiao-Lin Wang
A novel reaction that generates 1,5-disubstituted carbohydrazones via the carbonylation of tosylhydrazones has been developed. For the first time, the inexpensive, readily available, environmentally friendly, and nongaseous potassium carbonate is used as the carbonyl donor for the transformation. The reaction system exhibited tolerance with various functional groups and affords the desired products in good to excellent yields. This reaction is expected to be a powerful tool for the synthesis of carbohydrazone compounds.