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Efficient One-Pot, Two-Step, Microwave-Assisted Procedure for the Synthesis of Polysubstituted 2-Aminoimidazoles

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journal contribution
posted on 07.12.2006, 00:00 by Denis S. Ermolat'ev, Eugene V. Babaev, Erik V. Van der Eycken
A microwave-assisted, one-pot, two-step protocol was developed for the construction of polysubstituted 2-aminoimidazoles. This process involves the sequential formation of imidazo[1,2-a]pyrimidinium salts from readily available 2-aminopyrimidines and α-bromocarbonyl compounds, followed by opening of the pyrimidine ring with hydrazine.