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Efficient Nickel-Mediated Intramolecular Amination of Aryl Chlorides

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journal contribution
posted on 31.05.2003, 00:00 by Rafik Omar-Amrani, Antoine Thomas, Eric Brenner, Raphaël Schneider, Yves Fort
The use of an in situ generated Ni(0) catalyst associated with 2,2‘-bipyridine or N,N-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene (SIPr) as a ligand and NaO-t-Bu as the base for the intramolecular coupling of aryl chlorides with amines is described. The procedure has been applied to the formation of five-, six-, and seven-membered rings.