American Chemical Society
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Efficient Diastereoselective Synthesis of Trifarane-Type Sesquiterpenes, Trifarienols A and B

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journal contribution
posted on 2009-05-01, 00:00 authored by Kazunori Takahashi, Ryuichi Akao, Toshio Honda
Diastereoselective total synthesis of trifarienols A and B, trifarane-type sesquiterpenes isolated from the Malaysian Cheilolejeunea trifaria, was achieved via an intramolecular Hosomi−Sakurai reaction of the aldehyde to construct a substituted bicyclo[3.3.1]nonane skeleton having the exo-methylene moiety of the target compounds in one step.