Efficient Copper-Free PdCl2(PCy3)2-Catalyzed
Sonogashira Coupling of Aryl Chlorides with
Terminal Alkynes

Yi, Chenyi; Hua, Ruimao

doi:10.1021/jo0525175.s001

jo0525175_si_001.pdf (2.53 MB)

Efficient Copper-Free PdCl₂(PCy₃)₂-Catalyzed Sonogashira Coupling of Aryl Chlorides with Terminal Alkynes

journal contribution

posted on 2006-03-17, 00:00 authored by Chenyi Yi, Ruimao Hua

Under copper-free conditions and with Cs₂CO₃ as a base, PdCl₂(PCy₃)₂ showed high catalytic activity for cross-coupling of electron-rich, electron-neutral, and electron-deficient aryl chlorides with a variety of terminal alkynes in DMSO at 100−120 °C affording internal arylated alkynes in good to excellent yields.