ol501967c_si_002.pdf (2.98 MB)
Efficient Copper-Catalyzed Trifluoromethylation of Aromatic and Heteroaromatic Iodides: The Beneficial Anchoring Effect of Borates
journal contribution
posted on 2014-08-15, 00:00 authored by Zsombor Gonda, Szabolcs Kovács, Csaba Wéber, Tamás Gáti, Attila Mészáros, András Kotschy, Zoltán NovákEfficient copper-catalyzed trifluoromethylation
of aromatic iodides
was achieved with TMSCF3 in the presence of trimethylborate.
The Lewis acid was used to anchor the in situ generated trifluoromethyl
anion and suppress its rapid decomposition. Broad applicability of
the new trifluoromethylating reaction was demonstrated in the functionalization
of different aromatic and heteroaromatic iodides.
