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Efficient Asymmetric Synthesis of (+)-SCH 351448

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journal contribution
posted on 18.08.2005, 00:00 authored by Sergei Bolshakov, James L. Leighton
An efficient and stereocontrolled total synthesis of (+)-SCH 351448, a novel activator of low-density lipoprotein receptor promoter, has been achieved with a longest linear sequence of 21 steps. Key steps include applications of the recently developed asymmetric allyl- and crotylsilane reagents and a new protodesilylative version of the tandem silylformylation/allylsilylation reaction, which provides an efficient synthesis of 1,5-syn-diols.