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Efficient Approach to Mesoionic Triazolo[5,1‑a]isoquinolium through Rhodium-Catalyzed Annulation of Triazoles and Internal Alkynes

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journal contribution
posted on 05.06.2015, 00:00 by Shixian Zhao, Ruicheng Yu, Wanzhi Chen, Miaochang Liu, Huayue Wu
Rhodium-catalyzed annulation reactions between triazoles and internal alkynes, leading to various mesoionic isoquinoliums, are described. The reaction involves sequential triazole-directed C–H activation and C–C, C–N, and C–O bond formation processes in a one-pot manner. The starting materials and catalysts are easily available. The reaction offers a facile and practical approach to mesoionic isoquinolium derivatives.