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Efficient 1,4-Addition of Enones and Boronic Acids Catalyzed by a Ni–Zn Hydroxyl Double Salt-Intercalated Anionic Rhodium(III) Complex

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posted on 2014-11-07, 00:00 authored by Takayoshi Hara, Nozomi Fujita, Nobuyuki Ichikuni, Karen Wilson, Adam F. Lee, Shogo Shimazu
Intercalation of an in situ prepared [Rh­(OH)6]3– complex into an anion exchangeable Ni–Zn layered hydroxy double salt (Rh/NiZn) was demonstrated. The resulting Rh/NiZn effectively catalyzed the 1,4-addition of diverse enones and phenylboronic acids to their corresponding β-substituted carbonyl compounds. In the case of 2-cyclohexen-1-one and phenylboronic acid, a turnover frequency (TOF) of 920 h–1 based on Rh was achieved. The [Rh­(OH)6]3– complex maintained its original monomeric trivalent state within the NiZn interlayer following catalysis, attributable to a strong electrostatic interaction between the NiZn host and anionic Rh­(III) complex.

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