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Effects of Standardized Medicinal Plant Extracts on Drug Metabolism Mediated by CYP3A4 and CYP2D6 Enzymes
journal contribution
posted on 2020-08-14, 18:34 authored by Clarissa Feltrin, Ingrid Vicente Farias, Louis Pergaud Sandjo, Flávio Henrique Reginatto, Cláudia Maria Oliveira SimõesThe use of medicinal plants concomitantly
with conventional drugs
can result in herb–drug interactions that cause fluctuations
in drug bioavailability and consequent therapeutic failure and/or
toxic effects. The CYP superfamily of enzymes plays an important role
in herb–drug interactions. Among CYP enzymes, CYP3A4 and CYP2D6
are the most relevant since they metabolize about 50% and 30% of the
drugs on the market, respectively. Thus, the main goal of this study
was to evaluate the occurrence of in vitro interactions
between medicinal plant extracts and drug substrates of CYP3A4 and
CYP2D6 enzymes. Standardized extracts from nine medicinal plants (Bauhinia forficata, Cecropia glaziovii, Cimicifuga racemosa, Cynara scolymus, Echinacea sp., Ginkgo biloba, Glycine
max, Ilex paraguariensis, and Matricaria
recutita) were evaluated for their potential interactions
mediated by CYP3A4 and CYP2D6 enzymes. Among the extracts tested, C. glaziovii (red embaúba) showed the most relevant
inhibitory effects of CYP3A4 and CYP2D6 activity, while I.
paraguariensis (yerba mate) inhibited CYP3A4 activity. Both
extracts were chemically analyzed by UPLC-MS/MS, and these inhibitory
effects could lead to clinically potential and relevant interactions
with the drug substrates of these isoenzymes.