posted on 2021-05-28, 17:05authored byGarthika Navaranjan, Liisa M. Jantunen, Miriam L. Diamond, Shelley A. Harris, Sarah Bernstein, James A. Scott, Tim K. Takaro, Ruixue Dai, Diana L. Lefebvre, Piush J. Mandhane, Theo J. Moraes, Elinor Simons, Stuart E. Turvey, Malcolm R. Sears, Padmaja Subbarao, Jeffrey R. Brook
We
investigated the association between exposure to 29 organophosphate
esters (OPEs) and the onset of childhood asthma and recurrent wheeze.
Using a case-cohort design nested in the Canadian CHILD Cohort Study,
we included a random sample of children (n = 429),
all children with asthma at 5 years (n = 128), and
all children with recurrent wheeze between 2 and 5 years (n = 331). The association between 14 highly detected OPEs
measured in house dust vacuumed when children were 3–4 months
of age, including the child’s sleeping environment, and asthma
at 5 years and recurrent wheeze between 2 and 5 years was assessed
using logistic regression. The most abundant OPEs were TBOEP (median:
45730 ng/g) ≫ TCiPP (6065 ng/g) > TCEP (5260 ng/g) >
TPhP (4440
ng/g) > EHDPP (1750 ng/g). Concentrations were higher than those
in
most other studies worldwide, potentially due to the inclusion of
dust from the child’s sleeping area. A 2–4-fold increased
odds of asthma was observed across all quartiles of exposure to TBOEP
compared to the lowest quartile, including a positive dose–response
relationship. Inverse relationships (p < 0.05)
were observed with the odds of asthma and recurrent wheeze for 24DiPPDPP,
B4tBPPP, tri-m-cresyl phosphate (TmCP), and EHDPP,
and between 4tBPDPP and odds of asthma.