posted on 2021-03-02, 17:04authored byBrittany
P. Rickard, Henry Ho, Jacqueline B. Tiley, Ilona Jaspers, Kim L. R. Brouwer
E-cigarette-related
hospitalizations and deaths across the U.S.
continue to increase. A high percentage of patients have elevated
liver function tests indicative of systemic toxicity. This study was
designed to determine the effect of e-cigarette chemicals on liver
cell toxicity. HepG2 cells were exposed to flavoring chemicals (isoamyl
acetate, vanillin, ethyl vanillin, ethyl maltol, l-menthol,
and trans-cinnamaldehyde), propylene glycol, and
vegetable glycerin mixtures, and cell viability was measured. Data
revealed that vanillin, ethyl vanillin, and ethyl maltol decreased
HepG2 cell viability; repeated exposure caused increased cytotoxicity
relative to single exposure, consistent with the hypothesis that frequent
vaping can cause hepatotoxicity.