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Dynamics and Efficiency of Hole Transport in LNA:DNA Hybrid Diblock Oligomers

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journal contribution
posted on 03.10.2012, 00:00 by Arun K. Thazhathveetil, Josh Vura-Weis, Anton Trifonov, Michael R. Wasielewski, Frederick D. Lewis
We report here the effect of replacing one or both of the purine or pyrimidine blocks of a diblock stilbene donor–acceptor capped hairpin with locked nucleic acid (LNA) bases on the dynamics and efficiency of hole transport. The structures of the DNA and LNA:DNA hybrids are tentatively assigned to B- or A-type structures on the basis of their circular dichroism spectra. Replacing the bases in either the A-block or the G-block of the diblock DNA hairpin with LNA bases results in a modest decrease in the base-to-base hopping rate constant and quantum yield for charge separation. Somewhat larger decreases are observed when all of the purine or pyrimidine bases are replaced by LNA bases.