posted on 2019-07-01, 10:29authored byShou-Lei Li, Quan Wu, Chen Yang, Xin Li, Jin-Pei Cheng
Axially
chiral amides are usually found in many biologically active
compounds and are useful ligands in asymmetric catalysis. Herein,
by using the dynamic kinetic resolution approach, an asymmetric allylic
alkylation reaction of racemic amide naphthols is disclosed, which
leads to generation of the axially chiral naphthamides in good to
excellent yields (up to 97%) and enantioselectivities (up to 96:4
e.r.). Density functional theory was used to gain a theoretical understanding
of the enantioselectivities in this reaction.