Dynamic Kinetic Resolution of 2-Oxocycloalkanecarbonitriles: Chemoenzymatic Syntheses of Optically Active Cyclic β- and γ-Amino Alcohols
journal contributionposted on 15.08.2002, 00:00 by Juan R. Dehli, Vicente Gotor
A series of fungi and yeasts have been tested for the stereoselective bioreduction of 2-oxocycloalkanecarbonitriles, 1. The yeast Saccharomyces montanus CBS 6772 yielded the corresponding cis-hydroxy nitriles, 2, in >90% ee and de and in high chemical yields. Through simple and efficient procedures, they were transformed into optically active 2-amino and 2-aminomethyl cycloalkanols.