posted on 2020-08-08, 03:03authored byBaojian Xiong, Yue Li, Yin Wei, Søren Kramer, Zhong Lian
Cross-coupling
between substrates that can be easily derived from
phenols is highly attractive due to the abundance of phenols. Here,
we report a dual nickel-/palladium-catalyzed reductive cross-coupling
between aryl tosylates and aryl triflates; both substrates can be
accessed in just one step from readily available phenols. The reaction
has a broad functional group tolerance and substrate scope (>60
examples).
Furthermore, it displays low sensitivity to steric effects demonstrated
by the synthesis of a 2,2′-disubstituted biaryl and a fully
substituted aryl product. The widespread presence of phenols in natural
products and pharmaceuticals allows for straightforward late-stage
functionalization, illustrated with examples such as ezetimibe and
tyrosine.