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Double Ring-Closing Approach for the Synthesis of 2,3,6,7-Substituted Anthracene Derivatives

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journal contribution
posted on 04.06.2020, 14:05 by Birgit Meindl, Katharina Pfennigbauer, Berthold Stöger, Martin Heeney, Florian Glöcklhofer
A method for the synthesis of 2,3,6,7-substituted anthracene derivatives, one of the most challenging anthracene substitution patterns to obtain, is presented. The method is exemplified by the preparation of 2,3,6,7-anthracenetetracarbonitrile and employs a newly developed, stable, protected 1,2,4,5-benzenetetracarbaldehyde as the precursor. The precursor can be obtained in two scalable synthetic steps from 2,5-dibromoterephthalaldehyde and is converted into the anthracene derivative by a double intermolecular Wittig reaction under very mild conditions, followed by a deprotection and intramolecular double ring-closing condensation reaction.