American Chemical Society
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Dolabellane Diterpenoids from the Xisha Soft Coral Clavularia viridis

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journal contribution
posted on 2022-01-13, 07:03 authored by Yuan Gao, Ye-Qing Du, Yi Zang, Hong-Chun Liu, Hai-Yan Wan, Jia Li, Xu-Wen Li, Yue-Wei Guo
Twelve new members (112) of the dolabellane family, co-occurring with three related known diterpenoids (1315), were isolated from the Xisha soft coral Clavularia viridis. Their structures were determined by extensive spectroscopic analysis, modified Mosher’s method, and X-ray diffraction analysis. Clavuperoxylides A (3) and B (4) represent the first examples of dolabellanes containing peroxyl groups, especially the novel peroxide bridge in 4, whereas clavufuranolides A–C (911) are the first example of dolabellane diterpenoids comprising a tetrahydrofuran ring. The possible biogenetic relationship of all the isolates was proposed. In bioassay, several compounds exhibited considerable cytotoxicity against A549 and P388 cell lines. Compound 7 exhibited inhibitory activity against protein tyrosine phosphatases 1B (PTP1B), an anti-diabetic target, representing the first report of PTP1B inhibitory activity for dolabellane diterpenoids.