American Chemical Society
ol7b02464_si_001.pdf (2.61 MB)

Divinylsulfonamides as Specific Linkers for Stapling Disulfide Bonds in Peptides

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journal contribution
posted on 2017-09-07, 15:44 authored by Zhihong Li, Rong Huang, Hongtao Xu, Jiakang Chen, Yuexiong Zhan, Xianhao Zhou, Hongli Chen, Biao Jiang
A new class of N-phenyl-divinylsulfonamides which can be easily prepared have been successfully developed and utilized as efficient linkers in the field of disulfide bond modification. Functional divinylsulfonamides provide opportunities for the specific introduction of various functionalities, including affinity probes, fluorescent tags, and drugs, into peptides.