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Divergent Synthesis of Oxindolylidene Acetates and Spirooxindolopyrrolidones from Arynes

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journal contribution
posted on 07.03.2018, 14:15 by Virat G. Pandya, Santosh B. Mhaske
A novel process for the preparation of various (E)-oxindolylidene acetates using arynes and carbamoylpropiolates has been developed. The utility of this protocol is also further extended to the one-pot synthesis of complex spirooxindolopyrrolidones. This method provides a milder and transition-metal-free access to both of the target scaffolds in moderate to good yields.

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