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Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds

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journal contribution
posted on 25.04.2019, 00:00 authored by Keisuke Iida, Shunsuke Ishida, Takamichi Watanabe, Takayoshi Arai
Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives.