jo9b00769_si_001.pdf (8.74 MB)
Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds
journal contribution
posted on 2019-04-25, 00:00 authored by Keisuke Iida, Shunsuke Ishida, Takamichi Watanabe, Takayoshi AraiHerein,
a disulfide-catalyzed electrophilic iodination of aromatic
compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed.
The disulfide activates DIH as a Lewis base to promote the iodination
reaction in acetonitrile under mild conditions. This system is applicable
to a wide range of electron-rich aromatic compounds, including acetanilide,
anisole, imidazole, and pyrazole derivatives.