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Discovery of Turn-On Fluorescent Probes for Detecting Bcl‑2 Protein
journal contribution
posted on 2019-03-12, 00:00 authored by Tingting Liu, Gaopan Dong, Feng Xu, Bo Han, Hao Fang, Yun Huang, Yubin Zhou, Lupei Du, Minyong LiB-cell-lymphoma-2-gene
(Bcl-2) family proteins play a central role
in regulating programmed cell death. In cancer, antiapoptotic Bcl-2
proteins, such as Bcl-2 and Mcl-1, are overexpressed. However, there
are few developed labeling techniques for tracing the dynamic processes
of Bcl-2. To study the physiological process of Bcl-2 protein, a novel
series of small-molecule fluorescent probes (1–3) were designed and evaluated for their labeling properties.
Our probes can be applied to the identification of tumor-tissue slices
and the differentiation of tumor and normal tissues effectively, a
feature that renders these probes compatible with future cancer diagnosis
in clinical practice.