Discovery of
Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines
as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial
Infections

Hawryluk, Natalie; Robinson, Dale; Shen, Yixing; Kyne, Graham; Bedore, Matthew; Menon, Sanjay; Canan, Stacie; von Geldern, Thomas; Townson, Simon; Gokool, Suzanne; Ehrens, Alexandra; Koschel, Marianne; Lhermitte-Vallarino, Nathaly; Martin, Coralie; Hoerauf, Achim; Hernandez, Geraldine; Dalvie, Deepak; Specht, Sabine; Hübner, Marc Peter; Scandale, Ivan

doi:10.1021/acs.jmedchem.2c00960.s001

Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections

journal contribution

posted on 2022-08-16, 17:20 authored by Natalie Hawryluk, Dale Robinson, Yixing Shen, Graham Kyne, Matthew Bedore, Sanjay Menon, Stacie Canan, Thomas von Geldern, Simon Townson, Suzanne Gokool, Alexandra Ehrens, Marianne Koschel, Nathaly Lhermitte-Vallarino, Coralie Martin, Achim Hoerauf, Geraldine Hernandez, Deepak Dalvie, Sabine Specht, Marc Peter Hübner, Ivan Scandale

Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting about 145 million people worldwide. Efforts to control and eliminate onchocerciasis are impeded by a lack of effective treatments that target the adult filarial stage. Herein, we describe the discovery of a series of substituted di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as novel macrofilaricides for the treatment of human filarial infections.