Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B
Polymerase Inhibitors

Gopalsamy, Ariamala; Lim, Kitae; Ciszewski, Gregory; Park, Kaapjoo; Ellingboe, John W.; Bloom, Jonathan; Insaf, Shabana; Upeslacis, Janis; Mansour, Tarek S.; Krishnamurthy, Girija; Damarla, Murthy; Pyatski, Yelena; Ho, Douglas; Y. M. Howe, Anita; Orlowski, Mark; Feld, Boris; O'Connell, John

doi:10.1021/jm0401255.s001

jm0401255_si_001.pdf (65.97 kB)

Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors

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posted on 2004-12-16, 00:00 authored by Ariamala Gopalsamy, Kitae Lim, Gregory Ciszewski, Kaapjoo Park, John W. Ellingboe, Jonathan Bloom, Shabana Insaf, Janis Upeslacis, Tarek S. Mansour, Girija Krishnamurthy, Murthy Damarla, Yelena Pyatski, Douglas Ho, Anita Y. M. Howe, Mark Orlowski, Boris Feld, John O'Connell

A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.

Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors

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