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Discovery of New Tetracyclic Tetrahydrofuran Derivatives as Potential Broad-Spectrum Psychotropic Agents

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journal contribution
posted on 24.03.2005, 00:00 by Javier Fernández, José M. Alonso, José I. Andrés, José M. Cid, Adolfo Díaz, Laura Iturrino, Pilar Gil, Anton Megens, Victor K. Sipido, Andrés A. Trabanco
A series of novel tetracyclic tetrahydrofuran derivatives was prepared and evaluated for its potential psychotropic properties. In vitro affinities for multiple dopaminergic, serotonergic, α-adrenergic, and histamine receptors and for the norepinephrine transporter as well as the ED50 values obtained in some in vivo assays for antipsychotic, anxiolytic, and antidepressant potential are reported. Compounds (−)-1, (−)-8d, and (+)-8d have been identified as potential broad-spectrum psychotropic agents.