jm070638m_si_001.pdf (600.65 kB)

Discovery of 1,4-Didydroxy-2-naphthoate Prenyltransferase Inhibitors:  New Drug Leads for Multidrug-Resistant Gram-Positive Pathogens

Download (600.65 kB)
journal contribution
posted on 23.08.2007, 00:00 by Michio Kurosu, Prabagaran Narayanasamy, Kallolmay Biswas, Rakesh Dhiman, Dean C. Crick
Since utilization of menaquinone in the electron transport system is a characteristic of Gram-positive organisms, the 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) inhibitors 1a and 2a act as selective antibacterial agents against organisms such as methicillin-resistant Stapylococcus aureus (MRSA), Staphylococcus epidermidis (MRSE), and Mycobacterium spp. Growth of drug-resistant Gram-positive organisms was sensitive to the MenA inhibitors, indicating that menaquinone synthesis is a valid new drug target in Gram-positive organisms.

History

Exports