posted on 2021-04-12, 12:04authored byQian Xiao, Hong Zhang, Jing-Hong Li, Jing-Xin Jian, Qing-Xiao Tong, Jian-Ji Zhong
In
contrast with the well-developed radical thiol-ene reaction
to access anti-Markovnikov-type products, the research on the catalytic
Markovnikov-selective hydrothiolation of alkenes is very restricted.
Because of the catalyst poisoning of metal catalysts by organosulfur
compounds, limited examples of transition-metal-catalyzed thiol-ene
reactions have been reported. However, in this work, a directing-group-assisted
hydrothiolation of styrenes with thiols by photoredox/cobalt catalysis
is found to proceed smoothly to afford Markovnikov-type sulfides with
excellent regioselectivity.