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Directed Ortho Borylation of Phenol Derivatives Catalyzed by a Silica-Supported Iridium Complex

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journal contribution
posted on 17.09.2010, 00:00 by Kenji Yamazaki, Soichiro Kawamorita, Hirohisa Ohmiya, Masaya Sawamura
The directed ortho borylation of phenol derivatives protected with an N,N-diethylcarbamoyl group was efficiently catalyzed by an immobilized monophosphine−Ir system, which was prepared in situ from [Ir(OMe)(cod)]2 and a silica-supported, compact phosphine. The utility of the carbamoyloxy group as a leaving group for metal-catalyzed cross-coupling reactions was demonstrated by its utilization in the synthesis of a terphenyl derivative.