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Directed Denaturation:  Room Temperature and Stoichiometric Unfolding of Cytochrome c by a Metalloporphyrin Dimer

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journal contribution
posted on 21.03.2003, 00:00 by Andrew J. Wilson, Kevin Groves, Rishi K. Jain, Hyung Soon Park, Andrew D. Hamilton
Using circular dichroism, UV−vis, and trypsin proteolysis, we have shown how a metalloporphyrin dimer induces the unfolding of a protein, cytochrome c, under physiologically relevant conditions and accelerates its rate of proteolytic degradation.