ja7b09306_si_001.pdf (8.02 MB)
Directed γ‑C(sp3)–H Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox Catalysis
journal contribution
posted on 2017-10-12, 13:56 authored by Dian-Feng Chen, John C. K. Chu, Tomislav RovisVisible
light photoredox catalysis enables direct γ- C(sp3)–H alkylation of saturated aliphatic carbonyl compounds.
Electron-deficient alkenes are used as the coupling partners in this
reaction. Distinguished site selectivity is controlled by the predominant
1,5-hydrogen atom transfer of an amidyl radical generated in situ.