posted on 2024-02-17, 19:03authored byHuaxing Sun, Jing Wang, Zihang Du, Kun Zhang, Jiefeng Hu, Su Jing
The direct transformation of alkylboron has emerged as
a versatile
and powerful methodology for creating carbon–carbon and carbon–heteroatom
bonds. However, its potential application in the formation of carbon
and phosphorus remains unexplored. In this study, we present an alkoxide
base-promoted reaction system that enables deborylative phosphination
of benzylic organoboronates and geminal bis(boronates) via selective
C–B bond cleavage. This approach allows for the synthesis of
valuable tertiary phosphines in good yields under mild conditions.
The practicality and industrial potential of this approach are underscored
by the operational simplicity, broad substrate scope, and easy scalability.