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Direct Synthesis of Benzo[f]indazoles from Sulfonyl Hydrazines and 1,3-Enynes by Copper-Catalyzed Annulation

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journal contribution
posted on 21.12.2018, 21:04 by Biao Yao, Tao Miao, Pinhua Li, Lei Wang
A novel and efficient strategy for the direct synthesis of benzo­[f]­indazoles via copper-catalyzed cascade reaction of sulfonyl hydrazides with 1,3-enynes under mild conditions has been developed. This method achieves the formation of two C–N bonds and one C–C bond in one pot, providing a series of benzo­[f]­indazoles in moderate to good yields with good functional group tolerance and remarkable regioselectivity.