Direct Enantioselective Aldol−Tishchenko Reaction Catalyzed by Chiral Lithium Diphenylbinaphtholate

Chiral lithium diphenylbinaphtholate is an effective catalyst for the enantioselective aldol−Tishchenko reaction, affording 1,3-diol derivatives with three contiguous chiral centers and high stereoselectivities. Successive aldol−aldol−Tishchenko reactions gave a triol derivative with five consecutive chiral centers. The present reaction was applicable to highly enantioselective Evans−Tishchenko reduction.