American Chemical Society
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Direct Enantioselective Aldol−Tishchenko Reaction Catalyzed by Chiral Lithium Diphenylbinaphtholate

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journal contribution
posted on 2011-04-01, 00:00 authored by Tomonori Ichibakase, Makoto Nakajima
Chiral lithium diphenylbinaphtholate is an effective catalyst for the enantioselective aldol−Tishchenko reaction, affording 1,3-diol derivatives with three contiguous chiral centers and high stereoselectivities. Successive aldol−aldol−Tishchenko reactions gave a triol derivative with five consecutive chiral centers. The present reaction was applicable to highly enantioselective Evans−Tishchenko reduction.