American Chemical Society
Browse
ol103156h_si_001.pdf (1.31 MB)

Direct Enantioselective Aldol−Tishchenko Reaction Catalyzed by Chiral Lithium Diphenylbinaphtholate

Download (1.31 MB)
journal contribution
posted on 2011-04-01, 00:00 authored by Tomonori Ichibakase, Makoto Nakajima
Chiral lithium diphenylbinaphtholate is an effective catalyst for the enantioselective aldol−Tishchenko reaction, affording 1,3-diol derivatives with three contiguous chiral centers and high stereoselectivities. Successive aldol−aldol−Tishchenko reactions gave a triol derivative with five consecutive chiral centers. The present reaction was applicable to highly enantioselective Evans−Tishchenko reduction.

History