American Chemical Society
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Direct Conversion of β-Hydroxyketones to Cyclic Disiloxanes

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journal contribution
posted on 2010-11-19, 00:00 authored by Gregory W. O’Neil, Michael M. Miller, Kyle P. Carter
β-Hydroxyketones can be directly converted to cyclic disiloxanes using diphenylchlorosilane in the presence of imidazole and an amine base. The reaction is proposed to proceed via a nucleophilic activation mechanism through a cyclic chairlike transition state affording hydrosilylated products with high diastereoselectivity.