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Direct Construction of Fused Indoles by Gold-Catalyzed Cascade Cyclization of Conjugated Diynes

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posted on 2015-04-03, 00:00 authored by Saori Naoe, Tatsuo Saito, Masanobu Uchiyama, Shinya Oishi, Nobutaka Fujii, Hiroaki Ohno
A gold-catalyzed cascade cyclization of aniline derivatives bearing a conjugated diyne moiety was developed. Following the 5-endo-dig indole formation, subsequent 7-endo-dig cyclization predominated over 6-exo-dig cyclization to give the indole fused with a seven-membered ring in good yields.

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