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Direct Carbocyclization of Aldehydes with Alkynes:  Combining Gold Catalysis with Aminocatalysis

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journal contribution
posted on 06.03.2008, 00:00 by Jörg T. Binder, Benedikt Crone, Timm T. Haug, Helge Menz, Stefan F. Kirsch
A combination of gold(I) complexes and amine bases catalyzes the 5-exo-dig cyclization of formyl alkynes. This direct α-functionalization of aldehydes with unactivated alkynes does not involve the use of preformed enol equivalents.

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