American Chemical Society
jo5b00143_si_001.pdf (3.4 MB)

Direct Arylation of Sydnones with Aryl Chlorides toward Highly Substituted Pyrazoles

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journal contribution
posted on 2015-02-20, 00:00 authored by Andrew W. Brown, Joseph P. A. Harrity
The direct arylation of the C4 position of both N-alkyl- and N-arylsydnones with aryl/heteroaryl chlorides has been realized. The reaction is quite general and allows access to a wide range of 4-substituted sydnones. Yields of more challenging substrates can be improved through the use of aryl bromides.