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Direct Aldol Reactions Catalyzed by a Heterogeneous Guanidinium Salt/Proline System under Solvent-Free Conditions

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journal contribution
posted on 17.06.2011, 00:00 by Ángel Martínez-Castañeda, Belén Poladura, Humberto Rodríguez-Solla, Carmen Concellón, Vicente del Amo
The combined activity of (S)-proline and an achiral cocatalyst (a TBD-derived guanidinium salt) allow direct aldol reactions to be carried out with high diastereoselectivity and enantioselectivity under solvent-free conditions with a rather simple reaction setup where stirring is not required.

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