Direct Aldol Reactions Catalyzed by a Heterogeneous Guanidinium Salt/Proline System under Solvent-Free Conditions

Martínez-Castañeda, Ángel; Poladura, Belén; Rodríguez-Solla, Humberto; Concellón, Carmen; Amo, Vicente del

doi:10.1021/ol200890r.s001

ol200890r_si_001.pdf (2.91 MB)

Direct Aldol Reactions Catalyzed by a Heterogeneous Guanidinium Salt/Proline System under Solvent-Free Conditions

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posted on 2011-06-17, 00:00 authored by Ángel Martínez-Castañeda, Belén Poladura, Humberto Rodríguez-Solla, Carmen Concellón, Vicente del Amo

The combined activity of (S)-proline and an achiral cocatalyst (a TBD-derived guanidinium salt) allow direct aldol reactions to be carried out with high diastereoselectivity and enantioselectivity under solvent-free conditions with a rather simple reaction setup where stirring is not required.

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enantioselectivity guanidinium ConditionsThe aldol reactions diastereoselectivity Guanidinium Heterogeneou Direct Aldol Reactions Catalyzed reaction setup achiral cocatalyst

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Direct Aldol Reactions Catalyzed by a Heterogeneous Guanidinium Salt/Proline System under Solvent-Free Conditions

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