Direct Aldol Reactions Catalyzed by a Heterogeneous Guanidinium Salt/Proline System under Solvent-Free Conditions

Martínez-Castañeda, Ángel; Poladura, Belén; Rodríguez-Solla, Humberto; Concellón, Carmen; Amo, Vicente del

doi:10.1021/ol200890r.s001

Direct Aldol Reactions Catalyzed by a Heterogeneous Guanidinium Salt/Proline System under Solvent-Free Conditions

journal contribution

posted on 2011-06-17, 00:00 authored by Ángel Martínez-Castañeda, Belén Poladura, Humberto Rodríguez-Solla, Carmen Concellón, Vicente del Amo

The combined activity of (S)-proline and an achiral cocatalyst (a TBD-derived guanidinium salt) allow direct aldol reactions to be carried out with high diastereoselectivity and enantioselectivity under solvent-free conditions with a rather simple reaction setup where stirring is not required.