American Chemical Society
ol200890r_si_001.pdf (2.91 MB)

Direct Aldol Reactions Catalyzed by a Heterogeneous Guanidinium Salt/Proline System under Solvent-Free Conditions

Download (2.91 MB)
journal contribution
posted on 2011-06-17, 00:00 authored by Ángel Martínez-Castañeda, Belén Poladura, Humberto Rodríguez-Solla, Carmen Concellón, Vicente del Amo
The combined activity of (S)-proline and an achiral cocatalyst (a TBD-derived guanidinium salt) allow direct aldol reactions to be carried out with high diastereoselectivity and enantioselectivity under solvent-free conditions with a rather simple reaction setup where stirring is not required.