jo1c03149_si_001.pdf (1.83 MB)
Direct Aerobic α‑Hydroxylation of Arylacetates for the Synthesis of Mandelates
journal contribution
posted on 2022-03-04, 19:39 authored by Changming Xu, Xiangfan Li, Lei BaiAerobic α-hydroxylation of
α-methylene esters has proven
challenging due to overoxidation and hydrolysis of the materials.
In this article, KOtBu-promoted TBAB-catalyzed
α-hydroxylation of α-methylene aryl esters using O2 as the oxygen source has been developed. Both low reaction
temperature and catalyst TBAB are keys to success. This reaction provides
an environmentally friendly and low-cost approach to mandelates, which
are valuable building blocks and widely present in pharmaceuticals.