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Dipeptide Analogues Containing 4-Ethoxy-3-pyrrolin-2-ones

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journal contribution
posted on 11.05.2006, 00:00 by Masood Hosseini, Henriette Kringelum, Anthony Murray, Janne E. Tønder
Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.