posted on 2024-02-08, 15:40authored byIgnacio Fernández-Pastor, Francisco Javier Ortiz-López, Daniel Oves-Costales, Jesús Martín, Pilar Sánchez, Ángeles Melguizo, Fernando Reyes, Tilmann Weber, Olga Genilloud
Genome
analysis of strain Streptomyces sp.
CA-278952 revealed a biosynthetic gene cluster encoding a putative
lipopeptide with a sequence containing an Asp-Gly-Glu-Ala motif. We
envisioned that this motif could mimic the canonical Asp-X-Asp-Gly
sequence found in previously reported calcium-dependent lipopeptide
antibiotics. Chemical investigation of the producing strain led to
the discovery of three novel lipodepsipeptides, dilarmycins A–C.
The calcium-dependent antibacterial activity of the new compounds
was confirmed against the Gram-positive pathogens methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.