American Chemical Society
ja411325c_si_001.pdf (2.01 MB)

Differentially Instructive Extracellular Protein Micro-nets

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journal contribution
posted on 2014-06-04, 00:00 authored by Nilofar Faruqui, Angelo Bella, Jascindra Ravi, Santanu Ray, Baptiste Lamarre, Maxim G. Ryadnov
An ability to construct biological matter from the molecule up holds promise for applications ranging from smart materials to integrated biophysical models for synthetic biology. Biomolecular self-assembly is an efficient strategy for biomaterial construction which can be programmed to support desired function. A challenge remains in replicating the strategy synthetically, that is at will, and differentially, that is for a specific function at a given length scale. Here we introduce a self-assembly topology enabling a net-like architectural mimetic of native extracellular matrices capable of differential responses to cell adhesionenhanced mammalian cell attachment and proliferation, and enhanced resistance to bacterial colonizationat the native sub-millimeter length scales. The biological performance of such protein micro-nets directly correlates with their morphological and chemical properties, offering thus an application model for differential extracellular matrices.