Dienyl Homoallyl Alcohols via Palladium Catalyzed Ene-Type Reaction of Aldehydes with 1,3-Dienes

Fukushima, Masahiro; Takushima, Daiki; Kimura, Masanari

doi:10.1021/ja1072417.s001

Dienyl Homoallyl Alcohols via Palladium Catalyzed Ene-Type Reaction of Aldehydes with 1,3-Dienes

https://doi.org/10.1021/ja1072417.s001
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journal contribution

posted on 2010-11-24, 00:00 authored by Masahiro Fukushima, Daiki Takushima, Masanari Kimura

The combination of Pd catalyst and Xantphos ligand in the presence of Et<sub>3</sub>B nicely promotes the allylation of aldehydes with conjugated dienes to provide dienyl homoallyl alcohols in excellent yields. The reaction occurs selectively at the C−C double bond bearing higher electron density.