Diene−Titanium Complexes as Synthetic
Intermediates for the Construction of
Three- or Five-Membered Carbocycles

Bertus, Philippe; Menant, Christine; Tanguy, Chloé; Szymoniak, Jan

doi:10.1021/ol702917c.s002

Diene−Titanium Complexes as Synthetic Intermediates for the Construction of Three- or Five-Membered Carbocycles

journal contribution

posted on 2008-03-06, 00:00 authored by Philippe Bertus, Christine Menant, Chloé Tanguy, Jan Szymoniak

It has been shown that diene−titanium complexes exhibit substrate-dependent 1,2- or 1,4-dicarbanion reactivity. On this basis, 3-cyclopentenylamines and spiro-vinylcyclopropane lactams were easily prepared by using homoallylic Grignard reagents, Ti(O-i-Pr)₄, and nitriles or cyanoesters, respectively.

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exhibit diene nitrile Construction Ti basis reactivity complex CarbocyclesIt cyclopentenylamine cyanoester Complexe dicarbanion lactam homoallylic Grignard reagents Diene Synthetic Intermediates

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Diene−Titanium Complexes as Synthetic Intermediates for the Construction of Three- or Five-Membered Carbocycles

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