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Dicobalt Octacarbonyl Promoted Rearrangement of 4-Isoxazolines to Acylaziridines:  Dramatic Rate Acceleration with Very High Substrate Tolerance

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journal contribution
posted on 04.05.2002, 00:00 by Teruhiko Ishikawa, Takayuki Kudoh, Juri Yoshida, Ayako Yasuhara, Shinobu Manabe, Seiki Saito
Dicobalt octacarbonyl [Co2(CO)8] in acetonitrile at 75 °C triggers the cleavage of the N−O bond of 4-isoxazolines (1) to bring about the valence rearrangement to 2-acylaziridines (2). The isoxazolines were stable at 75 °C in the absence of the cobalt complex.

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