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Diastereoselective Synthesis of Cycloheptannelated Indoles via Lewis-Acid-Catalyzed (4 + 3)-Cyclization of Donor–Acceptor Cyclopropanes

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journal contribution
posted on 17.02.2020, 20:41 by Bao Qiong Li, Zong-Wang Qiu, Ai-Jun Ma, Jin-Bao Peng, Na Feng, Ji-Yuan Du, Han-Peng Pan, Xiang-Zhi Zhang, Xue-Tao Xu
An efficient and straightforward Lewis-acid-mediated stereoselective (4 + 3)-cyclization of indole-substituted alkylidene malonates and donor–acceptor cyclopropanes has been developed involving the Friedel–Crafts/Michael addition cyclization cascade. This reaction provides a mild and effective method for the construction of synthetically and structurally interesting functionalized cycloheptannelated indoles.

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