jo7b03161_si_001.pdf (2.14 MB)

Diastereo- and Enantioselective Synthesis of Spirooxindoles with Contiguous Tetrasubstituted Stereocenters via Catalytic Coupling of Two Tertiary Radicals

Download (2.14 MB)
journal contribution
posted on 06.02.2018, 00:00 by Zhi-Yong Song, Kun-Quan Chen, Xiang-Yu Chen, Song Ye
The oxidative N-heterocyclic carbene-catalyzed [3 + 2] annulation of β,β-disubstituted enals and dioxindoles was developed, giving the spirocyclic oxindole-γ-lactones bearing two contiguous tetrasubstituted stereocenters in good yields with excellent diastereoselectivities and good enantioselectivities.

History

Exports